Science

Intervention

New interventions and trials in primary care.

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  • We developed a network of researchers and established a database for intervention design to enable Australian trials of cognitive health to be compatible with planned or ongoing trials in Europe and the US. 
     
    Website: coghealth.net.au
     
    Publications

    • Anstey, K. J., Peters, R., Clare, L., Lautenschlager, N. T., Dodge, H. H., Barnes, D. E., ... & Rees, G. (2017). Joining forces to prevent dementia: the international research network on dementia prevention (IRNDP). International psychogeriatrics, 29(11), 1757-1760. https://www.ncbi.nlm.nih.gov/pubmed/28899450

  • The INDIGO trial investigates whether individual goal setting (the approach used was developed by CII in the UK) and peer mentoring from active same-aged community members can improve physical activity levels of non-demented sedentary older adults (60 years and older) with memory complaints. This project aims to conduct a long-term follow up of INDIGO participants 12 months after their last follow-up.
     
    Publications

    • Cox, K. L., Cyarto, E. V., Etherton-Beer, C., Ellis, K. A., Alfonso, H., Clare, L., ... & LoGiudice, D. (2017). A randomized controlled trial of physical activity with individual goal-setting and volunteer mentors to overcome sedentary lifestyle in older adults at risk of cognitive decline: the INDIGO trial protocol. BMC geriatrics, 17(1), 215. https://www.ncbi.nlm.nih.gov/pubmed/28903738

  • This project aims to develop a home-based, inexpensive, accessible interventions for older adults (60+ years). A pilot study will establish the feasibility of using: a) a Skype-type (an emerging intervention technology) real time home-based group exercise program, compared to b) an individual exercise program supported by a health tracker Fitbit (that provides feedback to the individual on amount and intensity of exercise taken, calories burned and time spent sleeping), and c) a centre-based group physical activity program. This pilot aims to determine relative feasibility and cost of the three interventions and the preferences of participants for a future efficacy trial. 

  • This trial of sitting restriction and physical activity to improve cognition in adults with type 2 diabetes (T2DM) is investigating whether sedentary adults with T2DM can adhere successfully to a 12-week intervention combining a sitting time reduction program with a home-based physical activity program. 

  • This project aims to compare an online risk reduction intervention to reduce risk of cognitive decline with a lifestyle modification in obese middle-aged adults in primary care. BBL-GP will evaluate and translate BBL to the primary care setting. Within primary care, a key population group for targeting with multi-domain risk reduction interventions is obese, middle-aged adults. Obesity in mid-life increases the risk of cognitive decline and doubles the risk of late-life dementia. BBL-GP engages participants in goal setting and behaviour change processes to reduce their overall risk profile for dementia. 
     
    Publications

    • Kim, S., McMaster, M., Torres, S., Cox, K. L., Lautenschlager, N., Rebok, G. W., ... & Anstey, K. J. (2018). Protocol for a pragmatic randomised controlled trial of Body Brain Life—General Practice and a Lifestyle Modification Programme to decrease dementia risk exposure in a primary care setting. BMJ open, 8(3), e019329. https://doi.org/10.1186/1745-6215-14-60

  • This project aims to conduct a 36-month follow-up assessment of a 24-month intervention trial that evaluates the effectiveness of physical activity in delaying the progression of cognitive decline and cerebrovascular disease in dementia-free participants of the AIBL cohort. 
     
    Publications

    • Cox, K. L., Cyarto, E. V., Ellis, K. A., Ames, D., Desmond, P., Phal, P., ... & You, E. (2018). A Randomized Controlled Trial of Adherence to a 24-Month Home-Based Physical Activity Program and the Health Benefits for Older Adults at Risk of Alzheimer’s Disease: The AIBL Active-Study. Journal of Alzheimer’s Disease, (Preprint), 1-19. https://www.ncbi.nlm.nih.gov/pubmed/30372680. 

  • As part of understanding the context for intervention development, we completed a scoping review of dementia primary prevention policies and strategies, led by Rachel Collins. 

    Publications

    • Collins, R., Silarova, B., & Clare, L. (2018). Dementia primary prevention policies and strategies and their local implementation: a scoping review using England as a case study. Journal of Alzheimer's Disease. DOI: 10.3233/JAD-180608. Advance online publication. https://www.ncbi.nlm.nih.gov/pubmed/30507574