Martin Bucknall

Principal Scientist (Small Molecule Analysis)
Adjunct Senior Lecturer

Currently Principal Scientist, BMSF and Adjunct Senior Lecturer, UNSW School of Optometry and Vision Science.

Martin P Bucknall graduated from the University of Manchester BSc Physics (1987), and subsequently worked as an Instrumentation Engineer with Waters Corporation in England.

In 1994 he joined the Inherited Diseases of Metabolism Research Group at the King Faisal Specialist Hospital and Research Centre, in Riyadh, Saudi Arabia, where he played a key role in setting up the first neonatal screening program for Inherited Errors of Metabolism (IEM’s) in the Middle East. The analytical approach involved rapidly quantifying acylcarnitines and amino acids in dried blood spots (collected on filter paper and mailed into the laboratory) using stable isotope dilution flow injection electrospray tandem mass spectrometry. A data reduction algorithm (CAMPA) to recognize abnormal metabolite levels was successfully developed and evaluated by Martin and the team. This facilitated quantitative analysis of more than 30,000 samples for 27 biomarkers in just 2 years, using a single instrument.

Martin moved to UNSW in 1998 and worked as Research Services Manager at the Biomedical Mass Spectrometry Unit, eventually enrolling to study part-time in the School of Physiology and Pharmacology (Faculty of Medicine) for a PhD. His PhD research “Dityrosine as a biomarker of free radical induced oxidative damage in diseases of ageing”, involved measuring nanomolar levels of o, o’-dityrosine, with high levels of specificity, in human biological matrices and attempting to correlate levels (normalized to tyrosine or creatinine) with states of inflammation and subject age.

Since graduating in 2007, Martin has been employed as Principal Scientist (Small Molecule Analysis) at the Bioanalytical Mass Spectrometry Facility (BMSF) in the Mark Wainwright Analytical Centre (MWAC) at UNSW Sydney.  His main role is the supervision of PhD and Postdoc work involving mass spectrometry for projects originating from research schools across the UNSW campus.

Martin also engages in commercial / legal / forensic analytical work and consulting.

Book Chapters
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Chandra-Hioe MV; Bucknall MP; Arcot J, 2015, 'Thiamin: Properties and Determination', in Caballero B; Finglas PM; Toldra F (ed.), Encyclopedia of Food and Health, Oxford Academic Press, UK, pp. 297 - 302, http://dx.doi.org/10.1016/B978-0-12-384947-2.00690-5
2015
Chandra-Hioe M; Bucknall ; Arcot , 2014, 'Applications of UPLC–MS/MS for the Quantification of Folate Vitamers', in Naushad M; Rizwan Khan M (ed.), Ultra Performance Liquid Chromatography Mass Spectrometry: Evaluation and Applications in Food Analysis, CRC Press, London, UK, pp. 115 - 128, http://dx.doi.org/10.1201/b16670
2014
Conference Papers
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Gibson E; Bucknall M; Golebiowski B; Wolffshohn J; Stapleton F, 2017, 'Detection of sex steroids and their metabolites in human tears using LC-MS/MS', in Detection of sex steroids and their metabolites in human tears using LC-MS/MS, ARVO Annual Meeting, Baltimore, USA, presented at ARVO Annual Meeting, Baltimore, USA, 07 May 2017 - 11 May 2017
2017
Koshy P; Choi SK; Adabifiroozjaei E; Gupta S; Sorrell CC; Bucknall M; Thomas D; Rawal A; Jang DM, 2017, 'Effect of Polymer Blending on the Properties of Coal Tars Produced by Pyrolysis', in Zeng Q; Bandyopadhyay S (ed.), Proceedings of iCMEMS Conference 2017, Science, Technology and Management Crest Australia, Sydney, pp. 45 - 50, presented at 1st International Conference on Mineral Engineering and Materials Science (iCMEMS2017), Sydney, 20 November 2017 - 22 November 2017
2017
Lim WW; Bucknall MP; Adler L; McKenzie DR; Suaning GJ, 2015, 'On the use of test gases of various radii to investigate molecular sieving in leak channels', in On the use of test gases of various radii to investigate molecular sieving in leak channels, IEEE, Milan, Italy, pp. 813 - 816, presented at 37th Annual International Conference of the IEEE, Milan, Italy, 25 August 2015 - 29 August 2015, http://dx.doi.org/10.1109/EMBC.2015.7318486
2015
Bucknall, Martin P ; Chandra-Hioe, Maria Veronica ; Arcot, Jayashree , 2013, 'A practical approach toward monitoring folic acid levels in food. A first look at whether Australian breads and bread-making flour contain the fortified folate levels mandated in 2009.', in Khairallah, George (ed.), ANZSMS24 Conference Program, 24th Australian and New Zealand Society for Mass Spectrometry, Trinity College (University of Melbourne), Parkville, Victoria, Australia, presented at 24th Australian and New Zealand Society for Mass Spectrometry, Trinity College (University of Melbourne), Parkville, Victoria, Australia, 02 February 2013 - 06 February 2013
2013
Chandra-hioe M; Bucknall MP; Arcot J, 2011, 'Ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS): development, optimisation and validation of the method used for folate analysis in foods', in Technology for Food Quality, Technology for Food Quality, Australia, pp. 12 - 18, presented at 12th Government Food Analysts Conference, Brisbane Australia, 22 February 2011 - 24 February 2011
2011
Conference Posters
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Chandra-hioe M; Bucknall MP; Pickford R; Arcot J, 2010, 'The Levels of Folic Acid and 5-Methyl Tetrahydrofolate in Australian Fortified Breads', Copenhagen, presented at 1st International Vitamin Conference, Copenhagen, 19 May 2010 - 21 May 2010
2010
Chandra-hioe M; Bucknall MP; Pickford R; Arcot J, 2010, 'The levels of Folic Acid and 5-Methyl Tetra Hydrofolate in Australian fortified bread', Copenhagen, presented at 1st International Vitamin Conference, Copenhagen, 19 May 2010 - 21 May 2010
2010
Journal articles
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Yadav S; Dudchenko O; Esvaran M; Rosen B; Field M; Skvortsova K; Gopalakrishnan S; Keilwagen J; Cockran B; Manandhar B; Bucknall M; Bustamante S; Rasmussen J; Melvin R; Omer A; Colaric, Z; Chan E; Minoche A; Smith T; Gilbert T; Bogdanovic O; Zammit R; Thomas T; Aiden E; Ballard B, 2020, 'Desert Dingo (Canis lupus dingo) genome provides insights into their role in the Australian ecosystem', bioRix, http://dx.doi.org/10.1101/2020.11.15.384057
2020
Zamanipoor MH; Yakufu B; Tse E; Rezaeimotlagh A; Hook JM; Bucknall MP; Thomas DS; Trujillo FJ, 2020, 'Brewing coffee? – Ultra-sonication has clear beneficial effects on the extraction of key volatile aroma components and triglycerides', Ultrasonics Sonochemistry, vol. 60, http://dx.doi.org/10.1016/j.ultsonch.2019.104796
2020
Shi L; Bucknall MP; Young TL; Zhang M; Hu L; Bing J; Lee DS; Kim J; Wu T; Takamure N; McKenzie DR; Huang S; Green MA; Ho-Baillie AWY, 2020, 'Gas chromatography-mass spectrometry analyses of encapsulated stable perovskite solar cells', Science, vol. 368, pp. eaba2412 - eaba2412, http://dx.doi.org/10.1126/science.aba2412
2020
Phan MAT; Bucknall MP; Arcot J, 2019, 'Co-ingestion of red cabbage with cherry tomato enhances digestive bioaccessibility of anthocyanins but decreases carotenoid bioaccessibility after simulated in vitro gastro-intestinal digestion', Food Chemistry, vol. 298, pp. 125040, http://dx.doi.org/10.1016/j.foodchem.2019.125040
2019
Gibson E; Bucknall M; Golebiowski B; Stapleton F, 2019, 'Comparative limitations and benefits of liquid chromatography –mass spectrometry techniques for analysis of sex steroids in tears', Experimental Eye Research, vol. 179, pp. 168 - 178, http://dx.doi.org/10.1016/j.exer.2018.11.015
2019
Phan MAT; Bucknall MP; Arcot J, 2019, 'Interferences of anthocyanins with the uptake of lycopene in Caco-2 cells, and their interactive effects on anti-oxidation and anti-inflammation in vitro and ex vivo', Food Chemistry, vol. 276, pp. 402 - 409, http://dx.doi.org/10.1016/j.foodchem.2018.10.012
2019
Phan MAT; Bucknall MP; Arcot J, 2019, 'Effects on intestinal cellular bioaccessibility of carotenoids and cellular biological activity as a consequence of co-ingestion of anthocyanin- and carotenoid-rich vegetables', Food Chemistry, vol. 286, pp. 678 - 685, http://dx.doi.org/10.1016/j.foodchem.2019.02.046
2019
Phan MAT; Bucknall M; Arcot J, 2018, 'Effect of different anthocyanidin glucosides on lutein uptake by Caco-2 cells, and their combined activities on anti-oxidation and anti-inflammation in vitro and ex vivo', Molecules, vol. 23, http://dx.doi.org/10.3390/molecules23082035
2018
Phan MAT; Bucknall M; Arcot J, 2018, 'Interactive effects of β-carotene and anthocyanins on cellular uptake, antioxidant activity and anti-inflammatory activity in vitro and ex vivo', Journal of Functional Foods, vol. 45, pp. 129 - 137, http://dx.doi.org/10.1016/j.jff.2018.03.021
2018
Phan MAT; Paterson J; Bucknall M; Arcot J, 2018, 'Interactions between phytochemicals from fruits and vegetables: Effects on bioactivities and bioavailability', Critical Reviews in Food Science and Nutrition, vol. 58, pp. 1310 - 1329, http://dx.doi.org/10.1080/10408398.2016.1254595
2018
Saha B; Bucknall M; Arcot J; Driscoll R, 2018, 'Derivation of two layer drying model with shrinkage and analysis of volatile depletion during drying of banana', Journal of Food Engineering, vol. 226, pp. 42 - 52, http://dx.doi.org/10.1016/j.jfoodeng.2018.01.010
2018
Kumar U; Gaikwad V; Mayyas M; Bucknall M; Sahajwalla V, 2018, 'Application of High-Resolution NMR and GC-MS to Study Hydrocarbon Oils Derived from Noncatalytic Thermal Transformation of e-Waste Plastics', ACS Omega, vol. 3, pp. 9282 - 9289, http://dx.doi.org/10.1021/acsomega.8b01284
2018
Saha B; Bucknall MP; Arcot J; Driscoll R, 2018, 'Profile changes in banana flavour volatiles during low temperature drying', Food Research International, vol. 106, pp. 992 - 998, http://dx.doi.org/10.1016/j.foodres.2018.01.047
2018
Chandra-Hioe MV; Bucknall MP; Arcot J, 2017, 'Evaluating folate extraction from infant milk formulae and adult nutritionals: Enzymatic digestion versus enzyme-free heat treatment', Food Chemistry, vol. 234, pp. 365 - 371, http://dx.doi.org/10.1016/j.foodchem.2017.04.179
2017
Carthey AJR; Bucknall MP; Wierucka K; Banks P, 2017, 'Novel predators emit novel cues: a mechanism for prey naivety towards alien predators', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-16656-z
2017
Das B; Ezzedinloo L; Bhadbhade M; Bucknall MP; Colbran SB, 2017, 'Strategic design of a ruthenium catalyst for both CO2 reduction and H2O oxidation: The electronic influence of the co-ligands', Chemical Communications, vol. 53, pp. 10006 - 10009, http://dx.doi.org/10.1039/c7cc06294j
2017
Mayyas M; Pahlevani F; Bucknall M; Maroufi S; You Y; Liu Z; Sahajwalla V, 2017, 'Thermocatalytic Conversion of Automotive Shredder Waste and Formation of Nanocarbons as a Process Byproduct', ACS Sustainable Chemistry and Engineering, vol. 5, pp. 5440 - 5448, http://dx.doi.org/10.1021/acssuschemeng.7b00774
2017
Kumar RK; Shadie AM; Bucknall MP; Rutlidge H; Garthwaite L; Herbert C; Halliburton B; Parsons KS; Wark PAB, 2015, 'Differential injurious effects of ambient and traffic-derived particulate matter on airway epithelial cells', Respirology, vol. 20, pp. 73 - 79, http://dx.doi.org/10.1111/resp.12381
2015
Blake C; Austad J; Austin S; Bacler S; Barrett B; Bhandari S; Boison J; Brown A; Bucknall M; Campos-Giménez E; Cellar N; Cenky M; Christiansen S; Clifford R; Collison M; Cruijsen H; De Borba B; Deborde JL; De Guzman R; De Laat M; Deng XJ; De Vreeze M; Dubois-Lozier A; Ellefson WC; Embuscado M; Evers J; Feng P; Fruth J; Gill BD; Golay PA; Haselberger P; Holskey M; Holroyd S; Hostetler G; Huang M; Indyk H; Jacobs W; Jaudzems G; Jobgen E; Joseph G; Klarenbeek B; Kneeteman E; Kohler K; Konings EJM; Lacorn M; Liang LX; Lock S; Marley E; Martin F; McMahon A; Phillips MM; Messerly J; Mohindra D; Montgomery N; Mountford M; Nipales N; Ofitserova M; Pacquette L; Pan SJ; Phillips S; Poitevin E; Poland A; Rankin R; Reimann L; Reuther J; Rimmer CA; Romano J; Royce S; Salvati L; Schmitz D; Shippar J; Sliva M; Song A; Steele K; Sullivan D; Szpylka J; Thompson JJ; Thompson L; Thompson M; Torma L; Rodriguez MT; Vermeulen M; Wargo W; Wood L; Woollard D; Wolf W; Yang J; Zhao L; Zhou Y; Zywicki R; Coates S, 2015, 'Determination of fluoride in infant formula and adult/pediatric nutritional formula', Journal of AOAC International, vol. 98, pp. 1081 - 1082, http://dx.doi.org/10.5740/jaoac.int.SMPR2014.016
2015
Jacobs W; Feng P; Austad J; Austin S; Bacler S; Barrett B; Bhandari S; Blake C; Boison J; Brown A; Bucknall M; Campos-Giménez E; Cellar N; Cenky M; Christiansen S; Clifford R; Collison M; Cruijsen H; De Borba BD; Deborde JL; De Guzman R; De Laat M; Deng XJ; DeVreeze M; Dubois-Lozier A; Ellefson WC; Embuscado M; Evers J; Fruth J; Gill BD; Golay PA; Haselberger P; Holskey M; Holroyd S; Hostetler G; Huang M; Indyk H; Jaudzems G; Jobgen E; Joseph G; Klarenbeek B; Kneeteman E; Kohler K; Konings EJM; Lacorn M; Liang LX; Lock S; Marley E; Martin F; McMahon A; Phillips MM; Messerly J; Mohindra D; Montgomery N; Mountford M; Nipales N; Ofitserova M; Pacquette L; Pan SJ; Phillips S; Poitevin E; Poland A; Rankin R; Reimann L; Reuther J; Rimmer CA; Romano J; Royce S; Salvati L; Schmitz D; Shippar J; Sliva M; Song A; Steele K; Sullivan D; Szpylka J; Thompson JJ; Thompson L; Thompson M; Torma L; Rodriguez MT; Vermeulen M; Wargo W; Wood L; Woollard D; Wolf W; Yang J; Zhao L; Zhou Y; Zywicki R; Coates S, 2015, 'Determination of chloride in infant formula and adult/pediatric nutritional formula', Journal of AOAC International, vol. 98, pp. 1079 - 1080, http://dx.doi.org/10.5740/jaoac.int.SMPR2014.015
2015
Jacobs W; Feng P; Austad J; Austin S; Bacler S; Barrett B; Bhandari S; Blake C; Boison J; Brown A; Bucknall M; Campos-Giménez E; Cellar N; Cenky M; Christiansen S; Clifford R; Collison M; Cruijsen H; De Borba BD; Deborde JL; De Guzman R; De Laat M; Deng XJ; DeVreeze M; Dubois-Lozier A; Ellefson WC; Embuscado M; Evers J; Fruth J; Gill BD; Golay PA; Haselberger P; Holskey M; Holroyd S; Hostetler G; Huang M; Indyk H; Jaudzems G; Jobgen E; Joseph G; Klarenbeek B; Kneeteman E; Kohler K; Konings EJM; Lacorn M; Liang LX; Lock S; Marley E; Martin F; McMahon A; Phillips MM; Messerly J; Mohindra D; Montgomery N; Mountford M; Nipales N; Ofitserova M; Pacquette L; Pan SJ; Phillips S; Poitevin E; Poland A; Rankin R; Reimann L; Reuther J; Rimmer CA; Romano J; Royce S; Salvati L; Schmitz D; Shippar J; Sliva M; Song A; Steele K; Sullivan D; Szpylka J; Thompson JJ; Thompson L; Thompson M; Torma L; Rodriguez MT; Vermeulen M; Wargo W; Wood L; Woollard D; Wolf W; Yang J; Zhao L; Zhou Y; Zywicki R; Coates S, 2015, 'Determination of selected carotenoids in infant formula and adult/pediatric nutritional formula', Journal of AOAC International, vol. 98, pp. 1077 - 1078, http://dx.doi.org/10.5740/jaoac.int.SMPR2014.014
2015
Jacobs W; Feng P; Austad J; Austin S; Bacler S; Barrett B; Bhandari S; Blake C; Boison J; Brown A; Bucknall M; Campos-Giménez E; Cellar N; Cenky M; Christiansen S; Clifford R; Collison M; Cruijsen H; De Borba BD; Deborde JL; De Guzman R; De Laat M; Deng XJ; DeVreeze M; Dubois-Lozier A; Ellefson WC; Embuscado M; Evers J; Fruth J; Gill BD; Golay PA; Haselberger P; Holskey M; Holroyd S; Hostetler G; Huang M; Indyk H; Jaudzems G; Jobgen E; Joseph G; Klarenbeek B; Kneeteman E; Kohler K; Konings EJM; Lacorn M; Liang LX; Lock S; Marley E; Martin F; McMahon A; Phillips MM; Messerly J; Mohindra D; Montgomery N; Mountford M; Nipales N; Ofitserova M; Pacquette L; Pan SJ; Phillips S; Poitevin E; Poland A; Rankin R; Reimann L; Reuther J; Rimmer CA; Romano J; Royce S; Salvati L; Schmitz D; Shippar J; Sliva M; Song A; Steele K; Sullivan D; Szpylka J; Thompson JJ; Thompson L; Thompson M; Torma L; Rodriguez MT; Vermeulen M; Wargo W; Wood L; Woollard D; Wolf W; Yang J; Zhao L; Zhou Y; Zywicki R; Coates S, 2015, 'Determination of amino acids in infant formula and adult/pediatric nutritional formula', Journal of AOAC International, vol. 98, pp. 1073 - 1076, http://dx.doi.org/10.5740/jaoac.int.SMPR2014.013
2015
Luu W; Zerenturk EJ; Kristiana I; Bucknal MP; Sharpe LJ; Brown AJ, 2014, 'Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesi[s]', Journal of Lipid Research, vol. 55, pp. 410 - 420, http://dx.doi.org/10.1194/jlr.M043257
2014
McSkimming A; Diachenko V; London R; Olrich K; Onie CJ; Bhadbhade MM; Bucknall MP; Read RW; Colbran SB, 2014, 'An easy one-pot synthesis of diverse 2,5-di(2-pyridyl)pyrroles: a versatile entry point to metal complexes of functionalised, meridial and tridentate 2,5-di(2-pyridyl)pyrrolato ligands', Chemistry (Weinheim an der Bergstrasse, Germany), vol. 20, pp. 11445 - 11456, http://dx.doi.org/10.1002/chem.201402157
2014
Chandra-hioe M; Addepalli R; Osborne SA; Slapetova I; Whan R; Bucknall MP; Arcot J, 2013, 'Transport of folic acid across Caco-2 cells is more effective than 5-methyltetrahydrofolate following the in vitro digestion of fortified bread', Food Research International, vol. 53, pp. 104 - 109, http://dx.doi.org/10.1016/j.foodres.2013.03.044
2013
Chandra-Hioe MV; Bucknall MP; Arcot J, 2013, 'Folic Acid-fortified Flour: Optimised and Fast Sample Preparation Coupled with a Validated High-Speed Mass Spectrometry Analysis Suitable for a Fortification Monitoring Program', Food Analytical Methods, vol. 6, pp. 1416 - 1423, http://dx.doi.org/10.1007/s12161-012-9559-3
2013
Chandra-hioe M; Bucknall MP; Arcot J, 2011, 'Folate analysis in foods by UPLC-MS/MS: development and validation of a novel, high throughput quantitative assay; folate levels determined in Australian fortified breads.', Analytical and Bioanalytical Chemistry, vol. 401, pp. 1035 - 1042, http://dx.doi.org/10.1007/s00216-011-5156-3
2011
Stangoulis J; Tate M; Graham R; Bucknall MP; Palmer L; Boughton B; Reid R, 2010, 'The mechanism of boron mobility in wheat and canola phloem', Plant Physiology, vol. 153, pp. 876 - 881, http://dx.doi.org/10.1104/pp.110.155655
2010
Chen V; Chan R; Li H; Bucknall MP, 2007, 'Spatial distribution of foulants on membranes during ultrafiltration of protein mixtures and the influence of spacers in the feed channel', Journal of Membrane Science, vol. 287, pp. 79 - 87, http://dx.doi.org/10.1016/j.memsci.2006.10.017
2007
Swanson RL; Williamson JE; De Nys R; Kumar N; Bucknall MP; Steinberg PD, 2004, 'Induction of settlement of larvae of the sea urchin Holopneustes purpurascens by histamine from a host alga', Biological Bulletin, vol. 206, pp. 161 - 172, http://dx.doi.org/10.2307/1543640
2004
Chan R; Chen V; Bucknall MP, 2004, 'Quantitative Analysis of Membrane Fouling by Protein Mixtures Using MALDI-MS', Wiley Interscience (online), vol. 85, pp. 190 - 201, http://dx.doi.org/10.1002/bit.10866
2004
Bucknall MP; Duncan MW; Fung KY, 2002, 'Practical quantitative Biomedical Applications of MALDI-TOF Mass Spectrometry', Journal of the American Society for Mass Spectrometry, vol. 13, pp. 1015 - 1027, http://dx.doi.org/10.1016/S1044-0305(02)00426-9
2002
Rahbeeni Z; Vaz FM; Al-Hussein K; Bucknall MP; Ruiter J; Wanders RJ; Rashed MS, 2002, 'Identification of two novel mutations in OCTN2 from two Saudi patients with systemic carnitine deficiency', Journal of Inherited Metabolic Disease, vol. 25, pp. 363 - 369, http://dx.doi.org/10.1023/A:1020143632011
2002
Chan R; Chen V; Bucknall MP, 2002, 'Ultrafiltration of protein mixtures: measurement of apparent critical flux, rejection performance, and identification of protein deposition', Desalination, vol. 146, pp. 83 - 90, http://dx.doi.org/10.1016/S0011-9164(02)00493-9
2002
Soufi S; Rashed MS; Al Essa M; Bucknall MP; Refi A; Badaghesh F; Habib HS; Ozand PT, 1998, 'Glutaric acidemia type 1: First Saudi patient diagnosed by tandem mass spectrometry-based neonatal screening', Annals of Saudi Medicine, vol. 18, pp. 160 - 163, http://dx.doi.org/10.5144/0256-4947.1998.160
1998
Rashed MS; Bucknall MP; Little D; Awad A; Jacob M; Alamoudi M; Alwattar M; Ozand PT, 1997, 'Screening blood spots for inborn errors of metabolism by electrospray tandem mass spectrometry with a microplate batch process and a computer algorithm for automated flagging of abnormal profiles', Clinical Chemistry, vol. 43, pp. 1129 - 1141, http://dx.doi.org/10.1093/clinchem/43.7.1129
1997
Rashed MS; Ozand PT; Bucknall MP; Little D, 1995, 'Diagnosis of inborn errors of metabolism from blood spots by acylcarnitines and amino acids profiling using automated electrospray tandem mass spectrometry', Pediatric Research, vol. 38, pp. 324 - 331, http://dx.doi.org/10.1203/00006450-199509000-00009
1995

MRACI CChem (Chartered Chemist)

Adjunct Senior Lecturer, UNSW School of Optometry and Vision Science