J Bertran-Gonzalez

Neuromodulatory Systems & Behaviour team, head
Future Fellow (ARC)

Jan 2021 - Dec 2024: Australian research Council Future Fellow, Head of Neuromodulatory Systems & Behaviour Team, Decision Neuroscience Laboratory (School of Psychology, The University of New South Wales, Australia).

Sept 2019 - : Senior Lecturer, Head of Neuromodulatory Systems & Behaviour Team, Decision Neuroscience Laboratory (School of Psychology, The University of New South Wales, Australia).

Sept 2016 - Aug 2019: Australian Research Council DECRA Fellow based in the Decision Neuroscience Laboratory (School of Psychology, The University of New South Wales, Australia).

Nov 2012-Aug 2016: Research Fellow at the Clem Jones Centre for Ageing Dementia Research (Queensland Brain Institute, The University of Queensland, Australia). Director: Prof Jürgen Götz

Oct 2010-Oct 2012: Postdoctoral Researcher at the Behavioural Neuroscience Laboratory (Brain and Mind Centre, The University of Sydney, Australia). Supervisor: Prof. Bernard Balleine

Dec 2009-Sept 2010: Postdoctoral Researcher at U839 INSERM (Paris, France). Supervisor: Prof Jean-Antoine Girault

Sept 2007-Nov 2009: Doctoral Thesis (Université Pierre et Marie Curie; conferral date: 12 May 2010): In vivo study of segregated signaling responses of striatonigral and striatopallidal neurons in BAC transgenic mice. Laboratory: Neurotransmission and signaling (UPMC, Paris, France) Supervisor: Dr Denis Hervé/Prof Jean-Antoine Girault. Qualification: Special Mention

Jan-July 2007: Master project in Biomedical Research (BIOMED). Laboratory : U839, INSERM (Paris, France). Supervisor : Dr Emmanuel Valjent

Sep-Dec 2006: Research stay at the Department of Neuropharmacology at the Universitat Pompeu Fabra (Barcelona). Supervisor: Prof. Rafael Maldonado.

Jan-June 2006: Graduation Project (Universitat Pompeu Fabra). Laboratory : U839, INSERM (Paris, France). Supervisor : Dr Emmanuel Valjent

2001-2006: Human Biology studies in the Health and Life Sciences Faculty (Universitat Pompeu Fabra, Barcelona)

Book Chapters
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Bertran-Gonzalez J; Laurent V, 2018, 'Chapter 10 Studying Integrative Processing and Prospected Plasticity in Cholinergic Interneurons The Importance of Pavlovian–Instrumental Transfer', in Goal-Directed Decision Making, pp. 221 - 241, http://dx.doi.org/10.1016/b978-0-12-812098-9.00010-3
2018
Bertran-Gonzalez J; Laurent V, 2018, 'Studying Integrative Processing and Prospected Plasticity in Cholinergic Interneurons: The Importance of Pavlovian–Instrumental Transfer', in Goal-Directed Decision Making Computations and Neural Circuits, Academic Press
2018
Conference Abstracts
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Matamales M; Skrbis Z; Balleine B; Goetz J; Bertran-Gonzalez J, 2015, 'Striatal deficits underlie conflicted patterns of action selection in ageing', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, Cairns, AUSTRALIA, Vol. 134, pp. 144 - 144, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, AUSTRALIA, 23 August 2015 - 27 August 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360206300331&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2015
Bertran-Gonzalez J; Goetz J; Balleine BW; Matamales M, 2015, 'Deficient corticostriatal activity in ageing shortens patterns of goal-directed action', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, Cairns, AUSTRALIA, Vol. 134, pp. 369 - 369, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, AUSTRALIA, 23 August 2015 - 27 August 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360206300947&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2015
Conference Papers
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Christie MJ; Enoksson T; Bertran-Gonzalez J, 2012, 'REWARDING AND AVERSIVE ACTIONS OF OPIOIDS DIFFERENTIALLY ACTIVATE D1-AND D2-RECEPTOR EXPRESSING NUCLEUS ACCUMBENS NEURONS', in ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, WILEY-BLACKWELL, Sapporo, JAPAN, pp. 40A - 40A, presented at 16th World Congress of the International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA), Sapporo, JAPAN, 09 September 2012 - 12 September 2012, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000308396700111&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2012
Journal articles
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Ztaou S; Oh SJ; Tepler S; Fleury S; Matamales M; Bertran-Gonzalez J; Chuhma N; Rayport S, 2021, 'Single dose of amphetamine induces delayed subregional attenuation of cholinergic interneuron activity in the striatum.', eNeuro, http://dx.doi.org/10.1523/ENEURO.0196-21.2021
2021
Balleine BW; Peak J; Matamales M; Bertran-Gonzalez J; Hart G, 2021, 'The dorsomedial striatum: an optimal cellular environment for encoding and updating goal-directed learning', Current Opinion in Behavioral Sciences, vol. 41, pp. 38 - 44, http://dx.doi.org/10.1016/j.cobeha.2021.03.004
2021
Morse AK; Leung BK; Heath E; Bertran-Gonzalez J; Pepin E; Chieng BC; Balleine BW; Laurent V, 2020, 'Basolateral Amygdala Drives a GPCR-Mediated Striatal Memory Necessary for Predictive Learning to Influence Choice', Neuron, vol. 106, pp. 855 - 869.e8, http://dx.doi.org/10.1016/j.neuron.2020.03.007
2020
Matamales M; McGovern AE; Mi JD; Mazzone SB; Balleine BW; Bertran-Gonzalez J, 2020, 'Local D2- To D1-neuron transmodulation updates goal-directed learning in the striatum', Science, vol. 367, pp. 549 - 555, http://dx.doi.org/10.1126/science.aaz5751
2020
Fisher SD; Ferguson LA; Bertran-Gonzalez J; Balleine BW, 2020, 'Amygdala-Cortical Control of Striatal Plasticity Drives the Acquisition of Goal-Directed Action', Current Biology, vol. 30, pp. 4541 - 4546.e5, http://dx.doi.org/10.1016/j.cub.2020.08.090
2020
Cummins N; Tweedie A; Zuryn S; Bertran-Gonzalez J; Götz J, 2019, 'Disease-associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria', EMBO Journal, vol. 38, http://dx.doi.org/10.15252/embj.201899360
2019
Bradfield LA; Matamales M; Bertran-Gonzalez J, 2018, 'The Thalamostriatal Pathway and the Hierarchical Control of Action', Neuron, vol. 100, pp. 521 - 523, http://dx.doi.org/10.1016/j.neuron.2018.10.041
2018
Doly S; Quentin E; Eddine R; Tolu S; Fernandez SP; Bertran-Gonzalez J; Valjent E; Belmer A; Viñals X; Callebert J; Faure P; Meye FJ; Hervé D; Robledo P; Mameli M; Launay JM; Maldonado R; Maroteaux L, 2017, 'Serotonin 2B receptors in mesoaccumbens dopamine pathway regulate cocaine responses', Journal of Neuroscience, vol. 37, pp. 10372 - 10388, http://dx.doi.org/10.1523/JNEUROSCI.1354-17.2017
2017
Matamales M; Skrbis Z; Bailey MR; Balsam PD; Balleine BW; Götz J; Bertran-Gonzalez J, 2017, 'A corticostriatal deficit promotes temporal distortion of automatic action in ageing', eLife, vol. 6, http://dx.doi.org/10.7554/eLife.29908
2017
Matamales M; Götz J; Bertran-Gonzalez J, 2016, 'Quantitative imaging of cholinergic interneurons reveals a distinctive spatial organization and a functional gradient across the mouse striatum', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0157682
2016
Matamales M; Skrbis Z; Hatch RJ; Balleine BW; Götz J; Bertran-Gonzalez J, 2016, 'Aging-Related Dysfunction of Striatal Cholinergic Interneurons Produces Conflict in Action Selection', Neuron, vol. 90, pp. 362 - 373, http://dx.doi.org/10.1016/j.neuron.2016.03.006
2016
Laurent V; Bertran-Gonzalez J; Chieng BC; Balleine BW, 2014, 'δ-Opioid and dopaminergic processes in accumbens shell modulate the cholinergic control of predictive learning and choice', Journal of Neuroscience, vol. 34, pp. 1358 - 1369, http://dx.doi.org/10.1523/JNEUROSCI.4592-13.2014
2014
Bonito-Oliva A; Pallottino S; Bertran-Gonzalez J; Girault JA; Valjent E; Fisone G, 2013, 'Haloperidol promotes mTORC1-dependent phosphorylation of ribosomal protein S6 via dopamine- and cAMP-regulated phosphoprotein of 32 kDa and inhibition of protein phosphatase-1', Neuropharmacology, vol. 72, pp. 197 - 203, http://dx.doi.org/10.1016/j.neuropharm.2013.04.043
2013
Bradfield LA; Bertran-Gonzalez J; Chieng B; Balleine BW, 2013, 'The Thalamostriatal Pathway and Cholinergic Control of Goal-Directed Action: Interlacing New with Existing Learning in the Striatum', Neuron, vol. 79, pp. 153 - 166, http://dx.doi.org/10.1016/j.neuron.2013.04.039
2013
Bertran-Gonzalez J; Laurent V; Chieng BC; Christie MJ; Balleine BW, 2013, 'Learning-related translocation of δ-Opioid receptors on ventral striatal cholinergic interneurons mediates choice between goal-directed actions', Journal of Neuroscience, vol. 33, pp. 16060 - 16071, http://dx.doi.org/10.1523/JNEUROSCI.1927-13.2013
2013
Enoksson T; Bertran-Gonzalez J; Christie MJ, 2012, 'Nucleus accumbens D2- and D1-receptor expressing medium spiny neurons are selectively activated by morphine withdrawal and acute morphine, respectively', Neuropharmacology, vol. 62, pp. 2463 - 2471, http://dx.doi.org/10.1016/j.neuropharm.2012.02.020
2012
Bertran-Gonzalez J; Chieng BC; Laurent V; Valjent E; Balleine BW, 2012, 'Striatal Cholinergic Interneurons Display Activity-Related Phosphorylation of Ribosomal Protein S6', PLoS ONE, vol. 7, http://dx.doi.org/10.1371/journal.pone.0053195
2012
Valjent E; Bertran-Gonzalez J; Bowling H; Lopez S; Santini E; Matamales M; Bonito-Oliva A; Hervé D; Hoeffer C; Klann E; Girault JA; Fisone G, 2011, 'Haloperidol regulates the state of phosphorylation of ribosomal protein S6 via activation of PKA and phosphorylation of DARPP-32', Neuropsychopharmacology, vol. 36, pp. 2561 - 2570, http://dx.doi.org/10.1038/npp.2011.144
2011
Bertran-Gonzalez J; Napier IA, 2011, 'Toward a model of retrograde regulation of striatal synaptic depression', Journal of Neuroscience, vol. 31, pp. 6944 - 6946, http://dx.doi.org/10.1523/JNEUROSCI.1133-11.2011
2011
Bertran-Gonzalez J; Hervé D; Girault JA; Valjent E, 2010, 'What is the degree of segregation between striatonigral and striatopallidal projections?', Frontiers in Neuroanatomy, http://dx.doi.org/10.3389/fnana.2010.00136
2010
Valjent E; Bertran-Gonzalez J; Aubier B; Greengard P; Hervé D; Girault JA, 2010, 'Mechanisms of locomotor sensitization to drugs of abuse in a two-injection protocol', Neuropsychopharmacology, vol. 35, pp. 401 - 415, http://dx.doi.org/10.1038/npp.2009.143
2010
Bertran-Gonzalez J; Håkansson K; Borgkvist A; Irinopoulou T; Brami-Cherrier K; Usiello A; Greengard P; Hervé D; Girault JA; Valjent E; Fisone G, 2009, 'Histone H3 phosphorylation is under the opposite tonic control of dopamine D2 and adenosine A2A receptors in striatopallidal neurons', Neuropsychopharmacology, vol. 34, pp. 1710 - 1720, http://dx.doi.org/10.1038/npp.2008.228
2009
Valjent E; Bertran-Gonzalez J; Hervé D; Fisone G; Girault JA, 2009, 'Looking BAC at striatal signaling: cell-specific analysis in new transgenic mice', Trends in Neurosciences, vol. 32, pp. 538 - 547, http://dx.doi.org/10.1016/j.tins.2009.06.005
2009
Doly S; Bertran-Gonzalez J; Callebert J; Bruneau A; Banas SM; Belmer A; Boutourlinsky K; Hervé D; Launay JM; Maroteaux L, 2009, 'Role of serotonin via 5-HT2B receptors in the reinforcing effects of MDMA in mice', PLoS ONE, vol. 4, http://dx.doi.org/10.1371/journal.pone.0007952
2009
Matamales M; Bertran-Gonzalez J; Salomon L; Degos B; Deniau JM; Valjent E; Hervé D; Girault JA, 2009, 'Striatal medium-sized spiny neurons: Identification by nuclear staining and study of neuronal subpopulations in BAC transgenic mice', PLoS ONE, vol. 4, http://dx.doi.org/10.1371/journal.pone.0004770
2009
Stipanovich A; Valjent E; Matamales M; Nishi A; Ahn JH; Maroteaux M; Bertran-Gonzalez J; Brami-Cherrier K; Enslen H; Corbillé AG; Filhol O; Nairn AC; Greengard P; Hervé D; Girault JA, 2008, 'A phosphatase cascade by which rewarding stimuli control nucleosomal response', Nature, vol. 453, pp. 879 - 884, http://dx.doi.org/10.1038/nature06994
2008
Bertran-Gonzalez J; Bosch C; Maroteaux M; Matamales M; Hervé D; Valjent E; Girault JA, 2008, 'Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol', Journal of Neuroscience, vol. 28, pp. 5671 - 5685, http://dx.doi.org/10.1523/JNEUROSCI.1039-08.2008
2008
Valjent E; Corbillé AG; Bertran-Gonsalez J; Hervé D; Girault JA, 2006, 'Inhibition of ERK pathway or protein synthesis during reexposure to drugs of abuse erases previously learned place preference', Proceedings of the National Academy of Sciences of the United States of America, vol. 103, pp. 2932 - 2937, http://dx.doi.org/10.1073/pnas.0511030103
2006

2020 Dean of Science Early Career Excellence Award (UNSW)

2018 Goldstar Award (University of New South Wales)

2017 Paxinos-Watson Award (Australasian Neuroscience Society 2016)

2017 Scientific Mobility Program (Australian Academy of Science and Embassy of France)

2016 Discovery Early Career Research Award (Australian Research Council)

2013 Scientific Mobility Program (Australian Academy of Science and Embassy of France)

2008 Prix Forum FENS 2008 (Societé des Neurosciences, France)

2021-2023 ARC Discovery Project (CI1 Matamales; CI2 Bertran-Gonzalez) [DP210102700: $378,205]

2021-2024 ARC Future Fellowship [FT200100502: $912,402]

2019-2021 ARC Discovery Project (Lead CI) [DP190102511: $464,678]

2019-2021 NHMRC New Investigator Project Grant (CIA) [APP1165990: $397,754.12]

2016-2019 ARC Discovery Early Career Research Award [DE160101275: $375,000]

2018 UNSW Goldstar Award (Lead CI) [DP180102797: $40,000]

2016 UNSW Research Infrastructure Scheme (co-investigator) [RG163114: $200,000]

https://www.neuromodulab.org/

My team has a broad interest in Systems Neuroscience: we are particularly interested in studying how learning is encoded brain circuits, and how new behaviours that did not exist before imprint in neuronal circuits when they are generated, matured and adapted upon changes in environmental rules. We focus our studies on subcortical brain networks that generate and tightly organise voluntary behaviours, such as the striatum and the basal ganglia. We capitalise on basic learning theory, which allows us to generate accurate paradigms that expose very specific forms of learning in mice, and we deploy a series of quantitative fluorescence techniques as well as specific circuit tracing and manipulation in behaving animals to explore causation. We are also interested in studying how these systems decline with age, and how this decline precipitates certain age-associated pathologies such as apathy, Parkinson’s disease and related cognitive disorders.

NEUR3221 Neurophysiology (UNSW)

PSYC4103 Elective Course (UNSW)

Australasian Course in Advanced Neuroscience ACAN (Director of the Systems Neuroscience & Behaviour Theme, week 3)