Adam Martin

Adjunct Lecturer

BSc (Nanotechnology) (Honours) from Curtin University, 2003-2007. PhD in chemistry from the University of Western Australia, 2008-2011. Postdoctoral research associate, the University of Nottingham, 2011-2013. Postdoctoral research associate, the University of New South Wales, 2013-2016. NHRMC-ARC Dementia Research Development Fellow, 2016-current.

My research program encompasses both practical and fundamental aspects related to short peptide hydrogels. Within this framework, I am seeking to address fundamental questions about the mechanism behind hydrogel formation, which will lead to the improved and rational design of future gelators. I am developing structure-property relationships between families of gelators related either through their N-terminal capping group or amino acid sequence. This will allow for the evaluation of a number of factors including hydrophilicity, charge and hydrogen bonding potential, on the structure and function of short peptide hydrogels, again leading to shift away from empirical design of these molecules towards rational design strategies tailored for end-stage applications.

I also examine the applications of these functional materials, with a specific focus on using them for three dimensional cell culture. These short peptide hydrogels have a nanoscale structure which mimics the extracellular matrix (ECM), and their tuneable nature means that properties such as stiffness, mesh size and functionality can be controlled. This is especially important, as it has been shown that the nature of the ECM plays an important role in a number of processes, including stem cell differentiation. The homogeneity and self-assembled nature of short peptide hydrogels offers them advantages over current cell culture materials such as MatriGel, which is known for batch-to-batch variation. Within my research framework, short peptide hydrogels are used as three dimensional cell culture materials to study the effect of the ECM on the progression of Alzheimer's disease. The homogeniety and tunability of these hydrogel materials allows the early stages of plaque and tangle formation to be probed, and new diagnostic techniques developed.

Publications

Journal articles
add
Aghaei-Ghareh-Bolagh B; Guan J; Wang Y; Martin AD; Dawson R; Mithieux SM; Weiss AS, 2019, 'Optically robust, highly permeable and elastic protein films that support dual cornea cell types', Biomaterials, vol. 188, pp. 50 - 62, http://dx.doi.org/10.1016/j.biomaterials.2018.10.006
2019
Hayes FJ; Buchanan SW; Coleman B; Gordon AM; Reich PB; Thevathasan NV; Wright IJ; Martin AR, 2019, 'Intraspecific variation in soy across the leaf economics spectrum', Annals of Botany, vol. 123, pp. 107 - 120, http://dx.doi.org/10.1093/aob/mcy147
2019
Wong CK; Martin AD; Floetenmeyer M; Parton RG; Stenzel MH; Thordarson P, 2019, 'Faceted polymersomes: A sphere-to-polyhedron shape transformation', Chemical Science, vol. 10, pp. 2725 - 2731, http://dx.doi.org/10.1039/c8sc04206c
2019
Tómasson DA; Ghosh D; Kržišnik Z; Fasolin LH; Vicente AA; Martin AD; Thordarson P; Damodaran KK, 2018, 'Enhanced Mechanical and Thermal Strength in Mixed-Enantiomers-Based Supramolecular Gel', Langmuir, vol. 34, pp. 12957 - 12967, http://dx.doi.org/10.1021/acs.langmuir.8b02729
2018
Martin AD; Easun TL; Argent SP; Lewis W; Blake AJ; Schröder M, 2017, 'The effect of carboxylate position on the structure of a metal organic framework derived from cyclotriveratrylene', CrystEngComm, vol. 19, pp. 603 - 607, http://dx.doi.org/10.1039/c6ce01965j
2017
Moir M; Chua SW; Reekie T; Martin AD; Ittner A; Ittner LM; Kassiou M, 2017, 'Ring-opened aminothienopyridazines as novel tau aggregation inhibitors', MedChemComm, vol. 8, pp. 1275 - 1282, http://dx.doi.org/10.1039/c6md00306k
2017
Du EY; Martin AD; Heu C; Thordarson P, 2017, 'The Use of Hydrogels as Biomimetic Materials for 3D Cell Cultures', Australian Journal of Chemistry, vol. 70, pp. 1 - 8, http://dx.doi.org/10.1071/CH16241
2017
Jones CL; Marsden EA; Nevin A; Kariuki BM; Bhadbhade MM; Martin AD; Easun TL, 2017, 'Investigating the geometrical preferences of a flexible benzimidazolone-based linker in the synthesis of coordination polymers', Royal Society Open Science, vol. 4, http://dx.doi.org/10.1098/rsos.171064
2017
Martin AD; Wojciechowski JP; Robinson AB; Heu C; Garvey CJ; Ratcliffe J; Waddington LJ; Gardiner J; Thordarson P, 2017, 'Controlling self-assembly of diphenylalanine peptides at high pH using heterocyclic capping groups', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/srep43947
2017
McEwen H; Du EY; Mata JP; Thordarson P; Martin AD, 2017, 'Tuning hydrogels through metal-based gelation triggers', Journal of Materials Chemistry B, vol. 5, pp. 9412 - 9417, http://dx.doi.org/10.1039/C7TB02140B
2017
Rouse CK; Martin AD; Easton CJ; Thordarson P, 2017, 'A Peptide Amphiphile Organogelator of Polar Organic Solvents', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/srep43668
2017
Barker EC; Martin AD; Garvey CJ; Goh CY; Jones F; Mocerino M; Skelton BW; Ogden MI; Becker T, 2017, 'Thermal annealing behaviour and gel to crystal transition of a low molecular weight hydrogelator', Soft Matter, vol. 13, pp. 1006 - 1011, http://dx.doi.org/10.1039/c6sm02431a
2017
Wojciechowski JP; Martin AD; Mason AF; Fife CM; Sagnella SM; Kavallaris M; Thordarson P, 2017, 'Choice of Capping Group in Tripeptide Hydrogels Influences Viability in the Three-Dimensional Cell Culture of Tumor Spheroids', ChemPlusChem, vol. 82, pp. 383 - 389, http://dx.doi.org/10.1002/cplu.201600464
2017
Aldilla VR; Nizalapur S; Martin A; Marjo CE; Rich A; Yee E; Suwannakot P; Black DS; Thordarson P; Kumar N, 2017, 'Design, synthesis, and characterisation of glyoxylamide-based short peptides as self-assembled gels', New Journal of Chemistry, vol. 41, pp. 13462 - 13471, http://dx.doi.org/10.1039/c7nj02248d
2017
Martin AD; Wojciechowski JP; Warren H; In Het Panhuis M; Thordarson P, 2016, 'Effect of heterocyclic capping groups on the self-assembly of a dipeptide hydrogel', Soft Matter, vol. 12, pp. 2700 - 2707, http://dx.doi.org/10.1039/c6sm00025h
2016
Banik R; Roy S; Dlháň Ľ; Titiš J; Boča R; Kirillov AM; Martin AD; Bauza A; Frontera A; Rodríguez-Diéguez A; Salas JM; Das S, 2016, 'Self-assembly synthesis, structure, topology, and magnetic properties of a mononuclear Fe(iii)-violurate derivative: A combined experimental and theoretical study', Dalton Transactions, vol. 45, pp. 16166 - 16172, http://dx.doi.org/10.1039/c6dt03139k
2016
Martin AD; Wojciechowski JP; Bhadbhade MM; Thordarson P, 2016, 'A Capped Dipeptide Which Simultaneously Exhibits Gelation and Crystallization Behavior', Langmuir, vol. 32, pp. 2245 - 2250, http://dx.doi.org/10.1021/acs.langmuir.5b03963
2016
Martin AD; Britton J; Easun TL; Blake AJ; Lewis W; Schröder M, 2015, 'Hirshfeld surface investigation of structure-directing interactions within dipicolinic acid derivatives', Crystal Growth and Design, vol. 15, pp. 1697 - 1706, http://dx.doi.org/10.1021/cg5016934
2015
Hassan MM; Martin AD; Thordarson P, 2015, 'Macromolecular crowding and hydrophobic effects on Fmoc-diphenylalanine hydrogel formation in PEG:water mixtures', Journal of Materials Chemistry B, vol. 3, pp. 9269 - 9276, http://dx.doi.org/10.1039/c5tb02139a
2015
Boulos RA; Zhang F; Tjandra ES; Martin AD; Spagnoli D; Raston CL, 2014, 'Spinning up the polymorphs of calcium carbonate', Scientific Reports, vol. 4, http://dx.doi.org/10.1038/srep03616
2014
Martin AD; Robinson AB; Mason AF; Wojciechowski JP; Thordarson P, 2014, 'Exceptionally strong hydrogels through self-assembly of an indole-capped dipeptide', Chemical Communications, vol. 50, pp. 15541 - 15544, http://dx.doi.org/10.1039/c4cc07941h
2014
Martin AD; Houlihan E; Morellini N; Eggers PK; James E; Stubbs KA; Harvey AR; Fitzgerald M; Raston CL; Dunlop SA, 2012, 'Synthesis and toxicology of p-phosphonic acid calixarenes and O-alkylated analogues as potential calixarene-based phospholipids', ChemPlusChem, vol. 77, pp. 308 - 313, http://dx.doi.org/10.1002/cplu.201100081
2012
Martin AD; Raston CL, 2011, 'Multifunctional p-phosphonated calixarenes', Chemical Communications, vol. 47, pp. 9764 - 9772, http://dx.doi.org/10.1039/c1cc12048d
2011
Martin AD; Boulos RA; Iyer KS; Sobolev AN; Bond CS; Atwood JL; Dalgarno SJ; Raston CL, 2011, 'Solvent and hydrogen confinement in molecular capsules - Hirshfeld surface and molecular simulation analysis', Chemical Communications, vol. 47, pp. 9882 - 9884, http://dx.doi.org/10.1039/c1cc13038b
2011
Zou J; Martin AD; Zdyrko B; Luzinov I; Raston CL; Iyer KS, 2011, 'Pd-induced ordering of 2D Pt nanoarrays on phosphonated calix[4]arenes stabilised graphenes', Chemical Communications, vol. 47, pp. 5193 - 5195, http://dx.doi.org/10.1039/c1cc10408j
2011
Martin AD; Boulos RA; Hubble LJ; Hartlieb KJ; Raston CL, 2011, 'Multifunctional water-soluble molecular capsules based on p-phosphonic acid calix[5]arene', Chemical Communications, vol. 47, pp. 7353 - 7355, http://dx.doi.org/10.1039/c1cc11991e
2011
Martin AD; Boulos RA; Stubbs KA; Raston CL, 2011, 'Phosphonated calix[4]arene-based amphiphiles as scaffolds for fluorescent nano-fibres', Chemical Communications, vol. 47, pp. 7329 - 7331, http://dx.doi.org/10.1039/c1cc11614b
2011
Hartlieb KJ; Martin AD; Saunders M; Raston CL, 2010, 'Photochemical generation of small silver nanoparticles involving multi-functional phosphonated calixarenes', New Journal of Chemistry, vol. 34, pp. 1834 - 1837, http://dx.doi.org/10.1039/c0nj00356e
2010
Clark TE; Martin A; Makha M; Sobolev AN; Su D; Rohrs HW; Gross ML; Raston CL, 2010, 'Layered calcium structures of p-phosphonic acid o-methyl-calix[6]arene', Crystal Growth and Design, vol. 10, pp. 3211 - 3217, http://dx.doi.org/10.1021/cg1003484
2010
Martin AD; Sobolev AN; Raston CL, 2010, 'Mapping out the diversity of interplay of O-alkylated calix[4]arenes', CrystEngComm, vol. 12, pp. 2666 - 2668, http://dx.doi.org/10.1039/c003053h
2010
Martin AD; Hartlieb KJ; Sobolev AN; Raston CL, 2010, 'Hirshfeld surface analysis of substituted phenols', Crystal Growth and Design, vol. 10, pp. 5302 - 5306, http://dx.doi.org/10.1021/cg1011605
2010
Martin AD; Clark TE; Makha M; Sobolev AN; Raston CL, 2009, 'Aromatic solvent specific induced arrays of calix[5]arenes', Crystal Growth and Design, vol. 9, pp. 4864 - 4871, http://dx.doi.org/10.1021/cg900682c
2009
Martin AD; Sobolev AN; Spackman MA; Raston CL, 2009, 'Variable intercalation of calcium ions in bilayers of partially deprotonated p-phosphonic acid calix[4]arene', Crystal Growth and Design, vol. 9, pp. 3759 - 3764, http://dx.doi.org/10.1021/cg9004467
2009