About The Dean

Merlin Crossley


Professor Merlin Crossley

Professor Merlin Crossley completed his BSc degree at the University of Melbourne, majoring in genetics and microbiology. He moved to Oxford University supported by a Rhodes Scholarship to pursue his doctorate, and then did post-doctoral research at Oxford and at Harvard Medical School.
He returned to Australia in 1995 and held various positions at the University of Sydney, including Professor of Molecular Genetics 2005-9, Acting Dean of Science  2004, Director of Research for the College of Sciences and Technology 2005, and was Acting Deputy Vice-Chancellor Research 2006-8. At the end of 2009 he moved to UNSW to take up the position of Dean of Science.  
He has received several awards for his work on gene control including the Australian Academy of Science's Gottschalk Medal, the Royal Society of NSW's Edgeworth David Medal, the Australian Society for Biochemistry and Molecular Biology's Roche Medal, and the Julian Well's Medal from the Lorne Genome Conference.
Follow Merlin: Twitter @MerlinCrossley  |  The Conversation



Crossley Lab Research

The Role of Transcription Factors in Development and Disease

Merlin’s laboratory studies how human genes can be turned on and off by DNA-binding regulatory proteins, termed transcription factors. He investigates the fundamental mechanisms underlying specific gene control, in the context of diseases, such as cancer, diabetes, and sickle cell anemia. Read more about the Crossley Lab

Active Research Projects


Recent Publications

Wienert B; Funnell AP; Norton LJ; Pearson RC; Wilkinson-White LE; Lester K; Vadolas J; Porteus MH; Matthews JM; Quinlan KG; Crossley M, 2015, 'Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin.', Nature Communications, vol. 6, pp. 7085,

Dewi V; Kwok A; Lee S; Lee MM; Tan YM; Nicholas HR; Isono K; Wienert B; Mak KS; Knights AJ; Quinlan KG; Cordwell SJ; Funnell AP; Pearson RC; Crossley M, 2015, 'Phosphorylation of Kruppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomain-interacting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity.', Journal of Biological Chemistry, vol. 290, no. 13, pp. 8591 - 8605,

Clifton MK; Westman BJ; Thong SY; O?Connell MR; Webster MW; Shepherd NE; Quinlan KG; Crossley M; Blobel GA; Mackay JP, 2014, 'The Identification and Structure of an N-Terminal PR Domain Show that FOG1 Is a Member of the PRDM Family of Proteins', PLoS One, vol. 9, no. 8, pp. e106011 - e106011,

Reid A; Yücel D; Wood M; Llamosas E; Kant S; Crossley M; Nicholas H, 2014, 'The transcriptional repressor CTBP-1 functions in the nervous system of Caenorhabditis elegans to regulate lifespan.',Experimental Gerontology, vol. 60, pp. 153 - 165,

Yücel D; Hoe M; Llamosas E; Kant S; Jamieson C; Young PA; Crossley M; Nicholas HR, 2014, 'SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans.', Developmental Biology, vol. 392, no. 2, pp. 266 - 282,

Funnell AP; Crossley M, 2014, 'Hemophilia B Leyden and once mysterious cis-regulatory mutations.',Trends in Genetics, vol. 30, no. 1, pp. 18 - 23,

Knights AJ; Funnell AP; Pearson RC; Crossley M; Bell-Anderson KS, 2014, 'Adipokines and insulin action: A sensitive issue.', Adipocyte, vol. 3, no. 2, pp. 88 - 96,

Burdach J; Funnell AP; Mak KS; Artuz CM; Wienert B; Lim WF; Tan LY; Pearson RC; Crossley M, 2014, 'Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor.', Nucleic Acids Research, vol. 42, no. 1, pp. 276 - 289,

Ballester B; Medina-Rivera A; Schmidt D; Gonzàlez-Porta M; Carlucci M; Chen X; Chessman K; Faure AJ; Funnell AP; Goncalves A; Kutter C; Lukk M; Menon S; McLaren WM; Stefflova K; Watt S; Weirauch MT; Crossley M; Marioni JC; Odom DT; Flicek P; Wilson MD, 2014, 'Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways.', eLife, vol. 3, pp. e02626,

Funnell AP; Vernimmen D; Lim WF; Mak KS; Wienert B; Martyn GE; Artuz CM; Burdach J; Quinlan KG; Higgs DR; Whitelaw E; Pearson RC; Crossley M, 2014, 'Differential regulation of the ?-globin locus by Kruppel-like Factor 3 in erythroid and non-erythroid cells.', BMC Molecular Biology, vol. 15, pp. 8,

Mak KS; Burdach J; Norton LJ; Pearson RC; Crossley M; Funnell AP, 2014, 'Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor.',Genome Biology: biology for the post-genomic era, vol. 15, no. 4, pp. R58,