Study: Treating generational stress: are probiotics the answer?

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Wednesday, 11 January, 2017
Dan Wheelahan

For the first time, Australian researchers have found a link between a father's stress levels and learning and memory ability in his offspring, and that these negative effects can be reversed by probiotics.

The researchers say the discovery in rats opens the way for research into the clinical effectiveness of probiotics for the treatment of stress-related emotional health problems in children.

The UNSW research, published in the journal Psychological Science, revealed two novel findings related to the emergence and treatment of the generational effects of stress.

In the study, male rats were exposed to stressful periods of maternal separation early in life. After the male rats reproduced, the researchers found their male offspring had longer lasting and stronger fear memories as infants.

Caitlin Cowan

UNSW PhD student and co-lead author Caitlin Cowan says the strong fear memories were not seen in the offspring of fathers that had a normal upbringing.

“We assessed fear memory during infancy, which is important because behavioural changes can be early warning signs that are a useful target for intervention,” Cowan says.

Other research has shown that the inability to suppress fear memories following exposure therapy may be a factor in the maladaptive expression of fear in anxiety, trauma, or stress-related disorders.

The researchers’ second finding was that probiotics can protect against these generational ‘stress effects’.

“We demonstrated the effectiveness of this particular probiotic both as an active treatment when administered to infant rats and as a preventative treatment when administered to fathers before conception,” Cowan says.

The probiotic was composed of 95% Lactobacillus rhamnosus and 5% Lactobacillus helveticus.

Study senior author Professor Rick Richardson, from UNSW’s School of Psychology, says the findings suggest the probiotics’ mechanism of action may be linked with the dampening of stress activated hormones and pro-inflammatory immune-signalling pathways.

“While the mechanism of action is yet to be fully understood, the ease of administration, minimal risk, low cost, and general public acceptance of probiotics make them an ideal candidate to investigate as a first line of defence against stress-induced vulnerabilities,” Professor Richardson says.

“The fact that early life adversity is often linked with poor nutrition and gastrointestinal problems further strengthens the case for probiotic interventions in stress and mental illness.

“There is an increasing awareness of the important role the gut plays in mental health, and this work represents an exciting example of how clinical neuroscience research may lead to new, more effective treatments for psychological disorders," he says.

Media contact: Dan Wheelahan, 9385 1933, 0435 930 465,