Type of event:
This talk will focus on next-generation methods for imaging and probing aspects of metabolism.
The Australian Research Council Centre of Excellence for Nanoscale Biophotonics draws on key advances of the 21st century, nanoscience, light and information technologies to help understand life at the molecular level. This talk will focus on next-generation methods for imaging and probing aspects of metabolism. By retooling a microscope with modern light emitting diodes and powerful software, a commonly ignored trait inherent to all cells can be exploited: their individual colour expression. This hyperspectral imaging technique pioneered by our team allows precise quantification of the native fluorescent colour of cells and tissues. Through this approach, and by using “big data” and the high processing speeds of modern computers, it is now possible to non-invasively image aspects of biomolecular composition of cells and tissues of relevance to metabolism. As metabolic dysregulation is common across the spectrum of diseases, this next-generation methodology is able to detect major health conditions including neurodegeneration, cancer and diabetes.
Professor Ewa M. Goldys is Deputy Director of the Australian Research Council Centre of Excellence in Nanoscale Biophotonics (http://cnbp.org,au/ ) and she holds a Personal Chair in the Department of Physics and Astronomy at Macquarie University, Sydney, Australia. She is Fellow of the Optical Society and winner of the 2016 Australian Museum Eureka Prize for ‘Innovative Use of Technology’. Her research spans the interface of ultrasensitive optical characterization, biotechnology, materials science and photonics. A portfolio of her works is centred on the development and understanding of luminescence emission in doped nanocrystals where she developed advanced methods of synthesis and characterisation of fluorescent nanoparticles for applications in fluorescence labelling. Her expertise in ultrasensitive optical characterisation and nanotechnology led to the development of novel approaches to biochemical and medical sensing and diagnostics. Current projects focus on label-free non-invasive high content cellular imaging and characterisation of cell subpopulations and on nanoparticle chemical sensors.