UNSW - Science

About The Dean Professor Merlin Crossley

Merlin Crossley


Crossley Lab Research


The Role of Transcription Factors in Development and Disease

Read more about the Crossley Lab here: http://www.crossley.babs.unsw.edu.au/

We investigate how transcription factors control the differentiation of stem cells into differentiated lineages, including blood and fat cells. We aim to understand how the breakdown of differentiation leads to diseases, including cancer.

Currently the lab includes 2 Postdoctoral Fellows, 6 PhD students, 1 Honours student and 1 Research Assistant. One or more Honours or MPhil positions are available in the lab for 2012.

 


Active Research Projects

 

Publications

Wilkinson-White, L., Gamsjaeger, R., Dastmalchi, S., Weinert, B., Stokes, P., Crossley, M., Mackay, J.P. & Matthews, J.M. (2011)
Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1.
Proceedings of the National Academy of Sciences of the United States of America. 108(35): 14443-14448.

Turchinovich, G., Vu, T.T., Frommer, F., Kranich, J., Schmid, S., Alles, M., Loubert, J.B., Goulet, J.P., Zimber-Strobl, U., Schneider, P., Bachl, J., Pearson, R.C., Crossley, M., Agenes, F. & Kirberg, J. (2011)
Programming of marginal zone B cell fate by basic kruppel-like factor (BKLF/KLF3).
Blood. 117: 3780-3792.

Vu, T.T., Gatto, D., Turner, V., Funnell, A.P., Mak, K.S., Norton, L.J., Kaplan, W., Cowley, M.J., Agenes, F., Kirberg, J., Brink, R., Pearson, R.C. & Crossley, M. (2011)
Impaired B cell development in the absence of Kruppel-like Factor 3.
Journal of Immunology. 187: 5032-5042.

Pearson, R.C., Funnell, A.P. & Crossley, M. (2011)
The mammalian transcription factor Kruppel-like Factor 3 (KLF3/BKLF).
IUBMB Life. 63: 86-93.

Nunez, N., Clifton, M.M., Funnell, A.P., Artuz, C.M., Hallal, S., Quinlan, K.G., Font, J., Vandevenne, M., Setiyaputra, S., Pearson, R.C., Mackay, J.P. & Crossley, M. (2011)
The multi-zinc finger protein ZNF217 contacts DNA through a two-finger domain.
The Journal of Biological Chemistry. 286(44): 38190-38201.

Jack, B.H., Pearson, R. & Crossley, M. (2011)
C-terminal binding protein: A metabolic sensor implicated in regulating adipogenesis.
International Journal of Biochemistry and Cell Biology. 43(5): 693-696.

Wissmueller, S., Font, J., Liew, C.W., Cram, E.D., Schroeder, T., Turner, J., Crossley, M., Mackay, J.P. & Matthews, J.M. (2011)
Protein-protein interactions: Analysis of a false positive GST pulldown result.
Proteins - Structure Function and Bioinformatics. 79(8): 2365 – 2371.

Crossley, M., Mak, K.S., Funnell, A.P. & Pearson, R.C., (2011)
PU.1 and haematopoietic cell fate: Dosage matters.
International Journal of Cell Biology. pp. Art. No. 808524, 10.1155/2011/808524.

Crossley, M., Norton, L.J., Funnell, A.P. & Pearson, R.C. (2011)
Cellular reprogramming toward the erythroid lineage.
International Journal of Cell Biology, pp. Art. No. 501464, 10.1155/2011/501464.

Jack, B. & Crossley, M. (2010)
GATA Proteins Work Together with Friend of GATA (FOG) and C-terminal Binding Protein (CTBP) Co-regulators to Control.
The Journal of Biological Chemistry. 285(42): 32405 – 32414.

Pearson, R.C. & Crossley, M. (2010)
KLF3 regulates muscle-specific gene expression and synergizes with serum response factor on KLF binding site.
Molecular and Cellular Biology. 30: 3430 – 3443.