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In recent years, there have been several advances in the characterisation of the yeast methylproteome. How can we place this knowledge in a broader cellular context? In this talk, three venues of investigation will be discussed, from the systems to the molecular levels. With interactome annotation and network analysis, “interaction codes” including protein methylation events can be discovered. The careful analysis of protein methyltransferases by mass spectrometry revealed that these enzymes are highly modified and the potential targets of regulatory networks. Finally, with a novel analytical tool, field asymmetric ion mobility separation (FAIMS), better separation and identification of methylpeptides can be obtained, as well as insights on the chemical effects of side chain methylation on local chemistry of peptides.
Brazil-born Daniel Winter undertook his Bachelor’s and Master’s studies at the Université Paris Diderot (Paris VII). In 2013, he joined Professor Marc Wilkins’ team at UNSW, where he completed his PhD. During his studies in Sydney, Daniel mentored several undergraduate students and, together with Associate Professor Christopher Marquis, led the UNSW undergraduate teams in the high profile iGEM synthetic biology competition.